There is an interesting discussion on LinkedIn: “Exactly 1 year ago today I left my high-paying W2 job to start my own company. Here are 9 reasons why you should NOT do the same thing.” Link
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dmcommunity.org 
I remember 15 years ago being asked to share my experience running a successful R&D business with students of the Computer Science department at University College Cork who were about to graduate. Before my lecture, I witnessed a similar presentation given by an Irish scientist who built and ran one of the most successful businesses in the US. His first slide said: “So, you want to start your own business…”. And then the second slide stated: “DON’T!”